While a shared attribute of DNA ligases is their envelopment from the nicked duplex as a C-formed protein clamp, they carry out this feat through the use of remarkably various accent structural modules and domain topologies. As structural, biochemical, and phylogenetic insights coalesce, we could anticipate developments on numerous fronts, including (i) pharmacological targeting of ligases for antibacterial and anticancer therapies and (ii) the discovery and design of latest strand-sealing enzymes with special substrate specificities.

Human DNA ligases will also be candidate drug targets for adjuvant most cancers chemotherapy, predicated on potentiating the effects of DNA-detrimental antineoplastics by transiently impeding DNA repair in tumor cells.

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